Advance in liver-type fatty acid binding protein
نویسندگان
چکیده
منابع مشابه
Effects of feed restriction and dietary fat type on mRNA expression of liver fatty acid-binding protein (L-FABP) in broilers
Background: Liver fatty acid-binding protein (L-FABP) is the main cytosolic binding site for long chain fatty acids in hepatocytes. FABPs enhance the uptake of fatty acids into the cell by increasing their concentration due to decreasing concentration of unbound fatty acids inside the cell. Objectives: The aim of this study was to evaluate the effects of dietary unsaturated to saturated fatty a...
متن کاملUrinary Liver-Type Fatty Acid–Binding Protein and Progression of Diabetic Nephropathy in Type 1 Diabetes
OBJECTIVE Diabetic nephropathy (DN) has mainly been considered a glomerular disease, although tubular dysfunction may also play a role. This study assessed the predictive value for progression of a tubular marker, urinary liver-type fatty acid-binding protein (L-FABP), at all stages of DN. RESEARCH DESIGN AND METHODS At baseline, 1,549 patients with type 1 diabetes had an albumin excretion ra...
متن کاملUrinary Liver-Type Fatty Acid-Binding Protein Predicts Progression to Nephropathy in Type 1 Diabetic Patients
OBJECTIVE Urinary liver-type fatty acid-binding protein (u-LFABP) is a marker of tubulointerstitial inflammation and has been shown to be increased in patients with type 1 diabetes and is further increased in patients who progress to micro- and macroalbuminuria. Our aim was to evaluate u-LFABP as a predictor of progression to micro- and macroalbuminuria in type 1 diabetes. RESEARCH DESIGN AND...
متن کاملSex steroid modulation of fatty acid utilization and fatty acid binding protein concentration in rat liver.
The mechanism by which sex steroids influence very low density hepatic lipoprotein triglyceride production has not been fully elucidated. In previous studies we showed that [(14)C]oleate utilization and incorporation into triglycerides were greater in hepatocyte suspensions from adult female rats than from males. The sex differences were not related to activities of the enzymes of triglyceride ...
متن کاملClinical significance of urinary liver-type fatty acid-binding protein in patients with diabetic nephropathy.
Tubulointerstitial damage plays a crucial role in the progression of kidney diseases, including diabetic nephropathy (1). Among several distinct types of fatty acid– binding protein (FABP), liver-type FABP (L-FABP) is abundantly expressed in hepatocytes and constitutively expressed in proximal tubular cells of the kidney (2). L-FABP incorporates albumin-bound free fatty acids (FFAs) that are fi...
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ژورنال
عنوان ژورنال: World Chinese Journal of Digestology
سال: 2008
ISSN: 2219-2859
DOI: 10.11569/wcjd.v16.i31.3523